Whitney Sherman's creative output is multi-faceted.

Prior to her career as an award-winning illustrator, she has worked in design, advertising, packaging, and television. As undergraduate Chair of Illustration at MICA from 2000-2010, she grew the department into the largest at the College with innovative interdisciplinary courses, a concentration in book arts, and programming geared for the gaming industry. She is the founding Director of the MFA in Illustration Practice program, and co-founder of the new MA in Illustration at MICA. As Co-Director of Dolphin Press & Print @ MICA, she directed book and print projects with Henrik Drescher/Wu Wing Yee, Peter Kuper, and Michael Bartalos. Sherman's current work in limited edition house wares and prints, under the brand Pbody Dsign, represents her view of the illustrator's expanding roles.

Her clients include national magazines such as the NY Times, Business Week, Forbes, design firms such as Tolleson Design, Pentagram, Ronn Campisi Design, and Karnes-Prickett, national institutions such as the Templeton Foundation, Ad Council, Robert Wood Johnson Foundation, and the American Red Cross, and publishers such as Clarkson Potter, Random House, and St. Martin's Press. Her commission to create the art for the US Postal Service Breast Cancer Research Stamp, now in its 20th year, is the longest running postal issue in US history. It has raised over $83 million in research funding.

Sherman has illustrated several books, and recently wrote Playing with Sketches from which she has conducted workshops in Mexico, China and the US. She has contributed to The Education of an Illustrator, and Educating Illustrators, both by Marshall Arisman & Steve Heller.

Her illustration and design work has been exhibited at the Norman Rockwell Museum, National Postal Museum, Art Institute of Chicago, Israel Museum, Axis Gallery/Tokyo, and the Society of Illustrators Gallery of American Illustration in NY. Sherman initiated the exhibitions Comics on the Verge, and Another Voice : Political Illustration from The Progressive, 1982-1999 at MICA. Notable public lectures include the Hallmark Residency Lecturer at the University of Kansas and the Closing Keynote at the Educators Symposium at the Society of Illustrators NY. She was also President of ICON5, the national illustration conference in New York.

Recently, Sherman served as an associate editor and one of fifty authors on The History of Illustration text book, a new, comprehensive analysis of illustration practices throughout time and within cultures of the world. The book includes numerous color plates, an extensive timeline, and text boxes that examine illustration through theoretical and material perspectives.